Solitary neurofibroma

Biopsy of the lesion at scanning power shows laminar hyperkeratosis of the epidermis, slight irregular acanthosis, and a perivascular lymphocytic inflammatory infiltrate in the papillary and superficial reticular dermis (Fig. 3), in the mid reticular dermis there is an unencapsulated, poorly defined neoplasm, consisting of a symmetrically arranged proliferation of wavy spindle cells in fascicles, immersed in a fibromyxoid matrix (Fig. 4) also observed are nerve bundles which surround the subcutaneous tissue and are indeed the origin of the lesión. Higher magnification demonstrates an abundant fibromyxoid stroma, with unorganized spindle cells with wavy nuclei, basophils, and indistinct cytoplasmic borders (Fig. 5). Higher magnification shows that the wavy spindle cells are actually Schwann cells and perineural fibroblasts, interspersed with mast cells and axons in a myxoid stroma (Fig. 6). Prior to the study, patient gave written consent to the examination and biopsy after having been informed about the procedure.